Parallel RNA-strand recognition by 2′-amino-β-l-LNA

A short synthetic route to the first β-l-ribo configured locked nucleic acid (LNA), that is, 2′-amino-β-l-LNA thymine phosphoramidite 6, has been developed from bicyclic nucleoside 1. Incorporation of 2′-amino-β-l-LNA thymine monomers into α-DNA strands results in probes forming stable duplexes with complementary RNA in parallel orientation.

Graphical abstractThe synthesis of the first β-l-ribo configured LNA is reported. Incorporation of 2′-amino-β-l-LNA thymine monomers into α-DNA strands results in probes forming stable duplexes with complementary RNA in parallel orientation.Figure optionsDownload full-size imageDownload as PowerPoint slide