Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1363942 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A short synthetic route to the first β-l-ribo configured locked nucleic acid (LNA), that is, 2′-amino-β-l-LNA thymine phosphoramidite 6, has been developed from bicyclic nucleoside 1. Incorporation of 2′-amino-β-l-LNA thymine monomers into α-DNA strands results in probes forming stable duplexes with complementary RNA in parallel orientation.
Graphical abstractThe synthesis of the first β-l-ribo configured LNA is reported. Incorporation of 2′-amino-β-l-LNA thymine monomers into α-DNA strands results in probes forming stable duplexes with complementary RNA in parallel orientation.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
T. Santhosh Kumar, Michael E. Østergaard, Pawan K. Sharma, Poul Nielsen, Jesper Wengel, Patrick J. Hrdlicka,