Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1363944 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
The C-cyclopropylalkylamide scaffold was previously identified as a new structural framework for antiestrogens. A second generation library provided three compounds that bind estrogen receptor (ER)α. Further screening of this library identified an ERβ hit and inspired another round of SAR. A new focused library was tested for binding to the ERs, and for effects on the growth of breast cancer cell lines and protein levels of common cell cycle regulators.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Miranda J. Sarachine, Jelena M. Janjic, Peter Wipf, Billy W. Day,