| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1363953 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
A water-soluble derivative of N-fused porphyrin (NFP) possessing a nona-arginine (R9) peptide tail was synthesized for the first time by a Cu(I)-catalyzed azide-alkyne ‘click’ reaction. In aqueous solution, at pH 8, the conjugated molecule (NFP-R9) exists as free base and protonated below pH < 6.5 to form monoprotonated species dominantly, and diprotonated one below pH < 2.3, while such clear two-step protonation behavior was not observed in the DMF solution.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yoshiya Ikawa, Hiroyuki Harada, Motoki Toganoh, Hiroyuki Furuta,