| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1363957 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A series of 3-(arylamino)-3-phenylpropan-2-olamines was prepared and screened for their ability to inhibit monoamine reuptake. A number of analogues displayed significant dual norepinephrine and serotonin reuptake inhibition. Compounds in this class exhibited minimal affinity for the dopamine transporter.
Graphical abstractA series of 3-(arylamino)-3-phenylpropan-2-olamines was prepared. A number of analogues displayed significant dual norepinephrine and serotonin reuptake inhibition. Compounds in this class exhibited minimal affinity for the dopamine transporter.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
An T. Vu, Stephen T. Cohn, Eugene A. Terefenko, William J. Moore, Puwen Zhang, Paige E. Mahaney, Eugene J. Trybulski, Igor Goljer, Rebecca Dooley, Jenifer A. Bray, Grace H. Johnston, Jennifer Leiter, Darlene C. Deecher,