| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1363958 | Bioorganic & Medicinal Chemistry Letters | 2009 | 6 Pages |
Abstract
Design, synthesis, and SAR of novel α-alkoxy-β-arylpropionic acids as potent and balanced PPARαγ coagonists are described. One representative thereof, Aleglitazar ((S)-2Aa), was chosen for clinical development. Its X-ray structure in complex with both receptors as well as its high efficacy in animal models of T2D and dyslipidemia are also presented.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Agnes Bénardeau, Jörg Benz, Alfred Binggeli, Denise Blum, Markus Boehringer, Uwe Grether, Hans Hilpert, Bernd Kuhn, Hans Peter Märki, Markus Meyer, Kurt Püntener, Susanne Raab, Armin Ruf, Daniel Schlatter, Peter Mohr,