| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1363966 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
The synthesis and SAR of a novel series of IKK2 inhibitors are described. Modification around the hinge binding region of the 7-azaindole led to a series of potent and selective inhibitors with good cellular activity.
Graphical abstractThe synthesis and SAR of 4-aryl-7-azaindoles as ATP-competitive IKK2 inhibitors is described. Modification around the hinge binding region of the 7-azaindole led to a series of potent and selective inhibitors with good cellular activity.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
John Liddle, Paul Bamborough, Michael D. Barker, Sebastien Campos, Rick P.C. Cousins, Geoffrey J. Cutler, Heather Hobbs, Duncan S. Holmes, Chris Ioannou, Geoff W. Mellor, Mary A. Morse, Jeremy J. Payne, John M. Pritchard, Kathryn J. Smith,