| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1363976 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
Isoindolo[2,1-b]isoquinolinones 9a–i were designed and synthesized as constrained forms of 3-arylisoquinolines through an intramolecular cyclization reaction. Among the synthesized compounds, 9d exhibited potent topoisomerase 1 inhibitory activity with cytotoxicities against three different tumor cell lines. A Surflex-dock docking study was performed to clarify the topoisomerase 1 inhibitory activity of 9d.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
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Authors
Hue Thi My Van, Won-Jea Cho,