New Labdane diterpenes as intestinal α-glucosidase inhibitor from antihyperglycemic extract of Hedychium spicatum (Ham. Ex Smith) rhizomes

Phytochemical investigation of antihyperglycemic extract of rhizomes of Hedychium spicatum led to the isolation of two new labdane type diterpenes 2, 3 along with seven known compounds (1, 4–9). Their structures were established on the basis of NMR (1D and 2D) and mass spectroscopic analysis. The new compound 2 displayed strong intestinal α-glucosidase inhibitory activity. Other compounds also displayed varying degree of intestinal α-glucosidase inhibitory potential.

Graphical abstractAntihyperglycemic extract of the rhizomes of Hedychiumspicatum yielded two new labdane diterpenes, spicatanol (2) and spicatanol methyl ether (3) as novel intestinal α-glucosidase inhibitors along with other known compounds, possessing varying degree of α-glucosidase inhibitory potentials.Figure optionsDownload full-size imageDownload as PowerPoint slide