| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1363983 | Bioorganic & Medicinal Chemistry Letters | 2009 | 6 Pages |
Abstract
The synthetic DOX–LNA conjugate was characterized by proton nuclear magnetic resonance and mass spectrometry. In addition, the purity of the conjugate was analyzed by reverse-phase high-performance liquid chromatography. The cellular uptake, intracellular distribution, and cytotoxicity of DOX–LNA were assessed by flow cytometry, fluorescence microscopy, liquid chromatography/electrospray ionization tandem mass spectrometry, and the tetrazolium dye assay using the in vitro cell models. The DOX–LNA conjugate showed substantially higher tumor-specific cytotoxicity compared with DOX.
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Related Topics
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Organic Chemistry
Authors
Meng-lei Huan, Si-yuan Zhou, Zeng-hui Teng, Bang-le Zhang, Xin-you Liu, Jie-pin Wang, Qi-bing Mei,