| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1363986 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
The synthesis, SAR and binding affinities are described for cannabinoid-1 receptor (CB1R) specific inverse agonists based on pyridopyrimidine and heterotricyclic scaffolds. Food intake and pharmacokinetic evaluation of several of these compounds indicate that they are effective orally active modulators of CB1R.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
John S. Debenham, Christina B. Madsen-Duggan, Junying Wang, Xinchun Tong, Julie Lao, Tung M. Fong, Marie-Therese Schaeffer, Jing Chen Xiao, Cathy C.R.-R. Huang, Chun-Pyn Shen, D. Sloan Stribling, Lauren P. Shearman, Alison M. Strack, D. Euan MacIntyre,