Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1364124 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
The development of a series of novel 4-substituted-2-aminopyrimidines as inhibitors of c-Jun N-terminal kinases is described. The synthesis, in vitro inhibitory values for JNK1, and the in vitro inhibitory value for a c-Jun cellular assay are discussed. Optimization of microsomal clearance led to the identification of 9c, whose kinase selectivity is reported.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Paul S. Humphries, Jennifer A. Lafontaine, Charles S. Agree, David Alexander, Ping Chen, Quyen-Quyen T. Do, Lilian Y. Li, Elizabeth A. Lunney, Ranjan J. Rajapakse, Karen Siegel, Sergei L. Timofeevski, Tianlun Wang, David M. Wilhite,