| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1364137 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
Various functionalized mono- and diarylanthranilo-1,3-dinitriles were synthesized and evaluated for their in vitro antihyperglycemic activity against the PTP-1B, glucose-6-phosphatase, glycogen phosphorylase and α-glucosidase enzymes. Among various screened compounds, 5,6-diaryl substituted anthranilo-1,3-dinitriles 3a, 3b, and 3d showed good inhibitory activity against PTP-1B with IC50 values of 58–72 μM. Three of the test compounds showed significant (25–37%) lowering of plasma glucose level at 24 h in sucrose-challenged streptozotocin-induced diabetic Sprague–Dawley rat model.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Fateh V. Singh, Amrita Parihar, Sumit Chaurasia, Amar B. Singh, Salil P. Singh, Akhilesh K. Tamrakar, Arvind K. Srivastava, Atul Goel,