Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1364154 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
A series of heterocyclic sulfonamides have been developed which are potent and selective inhibitors of hGlyT1. SAR studies to optimise the in vitro and in vivo properties are described. Optimisation of the central scaffold resulted in cyclohexane sulfones 28 and 29, which have good PK properties and show promise for further development.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Joanne L. Thomson, Wesley P. Blackaby, Andrew S.R. Jennings, Simon C. Goodacre, Andrew Pike, Steve Thomas, Terry A. Brown, Alison Smith, Gopalan Pillai, Leslie J. Street, Richard T. Lewis,