Article ID Journal Published Year Pages File Type
1364154 Bioorganic & Medicinal Chemistry Letters 2009 5 Pages PDF
Abstract
A series of heterocyclic sulfonamides have been developed which are potent and selective inhibitors of hGlyT1. SAR studies to optimise the in vitro and in vivo properties are described. Optimisation of the central scaffold resulted in cyclohexane sulfones 28 and 29, which have good PK properties and show promise for further development.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
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