| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1364158 | Bioorganic & Medicinal Chemistry Letters | 2009 | 6 Pages |
Abstract
A CXCR3 pocket capable of accommodating polycycloaliphatics was explored using a modular synthetic strategy. The systematic studies reveal that the tricyclic 2-adamantane and bicyclic (iso)bornyl group are efficiently recognized by CXCR3.
Graphical abstractThe strategic use of specific polycycloaliphatic groups in obtaining small antagonists for the CXCR3 receptor was investigated. 2-Adamantyl- and (iso)bornyl groups proved beneficial.Figure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Maikel Wijtmans, Dennis Verzijl, Cindy M.E. van Dam, Leontien Bosch, Martine J. Smit, Rob Leurs, Iwan J.P. de Esch,