| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1364169 | Bioorganic & Medicinal Chemistry Letters | 2009 | 6 Pages |
Abstract
New structural classes of KV1.3 and IK-1 ion channel blockers have been identified based on a virtual high throughput screening approach using a homology model of KcsA. These compounds display inhibitory effects on T-cell and/or keratinocyte proliferation and immunosuppressant activity within a DTH animal model.
Graphical abstractApplying vHTS based on a homology model, potent inhibitors of KV1.3 and IK-1 were identified.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Stefano Pegoraro, Martin Lang, Tobias Dreker, Jürgen Kraus, Svetlana Hamm, Cathal Meere, Juliane Feurle, Stefan Tasler, Sylvia Prütting, Zerrin Kuras, Violeta Visan, Stephan Grissmer,