Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility Part 1

The reported selective serotonin Re-uptake Inhibitor Litoxetine was used as the starting point in the design of a range of potential SSRIs with high ease of synthetic accessibility. Preparation and subsequent optimization yielded a range of potent and highly selective SSRIs.

Graphical abstractThe reported selective serotonin Re-uptake Inhibitor (SSRI) litoxetine was used as the starting point in the design of a range of potent, selective SSRIs with high ease of synthetic accessibility.Figure optionsDownload full-size imageDownload as PowerPoint slide