| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1364181 | Bioorganic & Medicinal Chemistry Letters | 2009 | 6 Pages |
Abstract
Soluble epoxide hydrolase (sEH) is a novel target for the treatment of hypertension and vascular inflammation. A new class of potent non-urea sEH inhibitors was identified via high throughput screening (HTS) and chemical modification. IC50s of the most potent compounds range from micromolar to low nanomolar.
Graphical abstractA class of potent non-urea inhibitors of soluble epoxide hydrolase was discovered via high throughput screening and SARs-guided modification.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Yuli Xie, Yidong Liu, Gangli Gong, Deborah H. Smith, Fang Yan, Alison Rinderspacher, Yan Feng, Zhengxiang Zhu, Xiangpo Li, Shi-Xian Deng, Lars Branden, Dušica Vidović, Caty Chung, Stephan Schürer, Christophe Morisseau, Bruce D. Hammock, Donald W. Landry,