| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1364337 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Pyrrospirones A and B have been isolated from unpolished rice cultures of the endophytic fungus Neonectria ramulariae Wollenw KS-246. Their absolute stereostructures (1 and 2) were elucidated through spectroscopic methods using 1D and 2D NMR techniques and chemical transformations, including the modified Mosher’s method. The compounds exhibited cytotoxicity and induced apoptosis in human promyelocytic leukemia HL-60 cells.
Graphical abstractPyrrospirones A and B have been isolated from the endophytic fungus Neonectria ramulariae Wollenw KS-246. The compounds exhibited cytotoxicity and induced apoptosis in human promyelocytic leukemia HL-60 cells.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yoshihito Shiono, Keiko Shimanuki, Fuminori Hiramatsu, Takuya Koseki, Murayama Tetsuya, Nozomi Fujisawa, Ken-ichi Kimura,