| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1364340 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
A series of 3,3-disubstituted pyrrolidine monoamine triple reuptake inhibitors were discovered. Analogues with low nanomolar potency, good human in vitro microsomal stability and in vitro permeability, and low drug–drug interaction potential are described. One example showed in vivo anti-depressant-like effects in the mouse tail suspension assay with a minimum effective dose of 30 mg/kg ip.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Linda M. Bannwart, David S. Carter, Hai-Ying Cai, Jason C. Choy, Robert Greenhouse, Saul Jaime-Figueroa, Pravin S. Iyer, Clara J. Lin, Eun Kyung Lee, Matthew C. Lucas, Stephen M. Lynch, Ann Marie Madera, Amy Moore, Kerem Ozboya, Lubica Raptova,