| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1364348 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
A successful scaffold-hopping approach gave a novel series of inhibitors of bacterial glutamate racemase (MurI). Early SAR studies of the 8-benzyl pteridine-6,7-diones led to compounds with micromolar enzyme potency and antibacterial activity.
Graphical abstractA successful scaffold-hopping approach gave a novel series of inhibitors of bacterial glutamate racemase (MurI). Early SAR studies of the 8-benzyl pteridine-6,7-diones led to compounds with micromolar enzyme potency and antibacterial activity.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gloria A. Breault, Janelle Comita-Prevoir, Charles J. Eyermann, Bolin Geng, Randy Petrichko, Peter Doig, Elise Gorseth, Brian Noonan,