| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1364354 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
We employed X-irradiation to activate a caged amino acid with a 2-oxoalkyl group. We designed and synthesized tyrosine derivative caged by a 2-oxoalkyl group (Tyr(Oxo)) to evaluate its radiolytic one-electron reduction characteristics in aqueous solution. Upon hypoxic X-irradiation, Tyr(Oxo) released a 2-oxopropyl group to form the corresponding uncaged tyrosine. In addition, radiolysis of dipeptides containing Tyr(Oxo) revealed that the efficiency of radiolytic removal of 2-oxopropyl group increased significantly by the presence of neighboring aromatic amino acids.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kazuhito Tanabe, Masahiko Ebihara, Nao Hirata, Sei-ichi Nishimoto,