| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1364355 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Three new phthalate acid derivatives, 2,12-diethyl-11-methylhexadecyl 2-ethyl-11-methylhexadecyl phthalate (1), 2-ethyldecyl 2-ethylundecyl phthalate (2), and bis(2-ethyldodecyl) phthalate (3), were isolated from seahorse, Hippocampus Kuda Bleeler, together with a known natural analog bis(2-ethylheptyl) phthalate (4). The structures of these compounds were elucidated mainly by means of the comprehensive analysis of their NMR spectroscopic data. The four phthalate derivatives showed dose-dependent cathepsin B inhibitions activities with IC50 values of 0.13 mΜ (1), 0.21 mΜ (2), 0.18 mΜ (3), and 0.29 mΜ (4), respectively.
Graphical abstractThree new phthalate acid derivatives, 2,12-diethyl-11-methylhexadecyl 2-ethyl-11-methylhexadecyl phthalate (1), 2-ethyldecyl 2-ethylundecyl phthalate (2), and bis(2-ethyldodecyl) phthalate (3), were isolated from seahorse, Hippocampus Kuda Bleeler, together with a known natural analog bis(2-ethylheptyl) phthalate (4). The four phthalate derivatives showed dose-dependent cathepsin B inhibitions activities with IC50 values of 0.13 mΜ (1), 0.21 mΜ (2), 0.18 mΜ (3), and 0.29 mΜ (4), respectively.Figure optionsDownload full-size imageDownload as PowerPoint slide
