| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1364377 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
High-throughput screening of the GSK compound collection against the P2Y1 receptor identified a novel series of tetrahydro-4-quinolinamine antagonists. Optimal substitution around the piperidine group was pivotal for ensuring activity. An exemplar analog from this series was shown to inhibit platelet aggregation.
Graphical abstractHigh-throughput screening of the GSK compound collection against the P2Y1 receptor identified a novel series of tetrahydro-4-quinolinamine antagonists. Optimal substitution around the piperidine group was pivotal for ensuring activity. An exemplar analog from this series was shown to inhibit platelet aggregation.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Ángel I. Morales-Ramos, John S. Mecom, Terry J. Kiesow, Todd L. Graybill, Gregory D. Brown, Nambi V. Aiyar, Elizabeth A. Davenport, Lorena A. Kallal, Beth A. Knapp-Reed, Peng Li, Allyn T. Londregan, Dwight M. Morrow, Shobha Senadhi, Reema K. Thalji,