Article ID Journal Published Year Pages File Type
1364381 Bioorganic & Medicinal Chemistry Letters 2008 4 Pages PDF
Abstract

The cation-independent mannose 6-phosphate receptor (CI-M6PR) is essential for the endocytosis of proteins bearing the mannose 6-phosphate (M6P) recognition marker. This study described the synthesis of M6P and M6S analogs presenting greater affinity for CI-M6PR than their natural compounds. Moreover, the finding of their lack of cytotoxicity for human cells and of their increased stability in human serum supports the high potential of these isosteric derivatives in therapies requiring CI-M6PR targeting.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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