Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1364393 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
The discovery and initial optimization of a novel anthranilic acid derived class of antibacterial agents has been described in a recent series of papers. This paper describes the discovery of 1-acylindazol-3-ols as a novel bioisostere of an anthranilic acid. The synthesis and structure–activity relationships of the indazol bioisosteres are described herein.
Graphical abstractThis paper describes the discovery of 1-acylindazol-3-ols as a novel bioisostere of an anthranilic acid. The synthesis and structure–activity relationships of the indazol bioisosteres are described herein.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Cory Stiff, David R. Graber, Atli Thorarensen, Brian D. Wakefield, Keith R. Marotti, Earline P. Melchior, Michael T. Sweeney, Fusen Han, Douglas C. Rohrer, Gary E. Zurenko, Donna L. Romero,