| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1364566 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Protein tyrosine phosphatases (PTPs) are cysteine-dependent enzymes that play a central role in cell signaling. Organic hydroperoxides cause thiol-reversible, oxidative inactivation of PTP1B in a manner that mirrors the endogenous signaling agent hydrogen peroxide.
Graphical abstractProtein tyrosine phosphatases (PTPs) are cysteine-dependent enzymes that play a central role in cell signaling. Organic hydroperoxides cause thiol-reversible, oxidative inactivation of PTP1B in a manner that mirrors the endogenous signaling agent hydrogen peroxide.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sanjib Bhattacharya, Jason N. LaButti, Derrick R. Seiner, Kent S. Gates,