Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1364569 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Two BODIPY-labeled colchicine derivatives were synthesized and shown to bind to tubulin but only partially inhibit tubulin polymerization in the presence of GTP. Cytotoxicity studies were carried out in HeLa, HepG2, Raji and Vero cells. Apoptosis-inducing properties were determined by caspase 3/7 activity and flow cytometry and interactions between the derivatives and tubulin were verified by fluorescence microscopy of living cells.
Graphical abstractPhoto-stable and pH-independent BODIPY-labeled colchicine analogs were synthesized to allow analysis of the cellular distribution of tubulin.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Leggy A. Arnold, Patricia Ranaivo, R. Kiplin Guy,