Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1364574 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Triphenylmethylamides (TPMAs) have been previously identified as compounds that arrest cells in the G1-phase of the cell cycle and induce apoptotic death in melanoma cell lines in culture. Here we report the synthesis of a series of TPMA derivatives, allowing the structure–activity relationship of this class of molecules to be established. Several new compounds have been identified that induce death in UACC-62 and SK-MEL-5 human melanoma cell lines, including a compound with enhanced aqueous solubility.
Graphical abstractThe optimization of triphenylmethylamides (TPMAs) as anticancer agents is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Rahul Palchaudhuri, Paul J. Hergenrother,