| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1364577 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Neighboring-group participation in the reaction catalyzed by purine nucleoside phosphorylase involves His257-facilitated compression of the 5â²- and 4â²-ribosyl oxygens. The His257Gly mutant opens a space for preferential binding of 5â²-substituted Immucillins, transition-state analogues of this reaction.
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Authors
Andrew S. Murkin, Keith Clinch, Jennifer M. Mason, Peter C. Tyler, Vern L. Schramm,