| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1364597 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
A focused library of N-aryl l-homoserine lactones was designed around known lactone leads and evaluated for antagonistic and agonistic activity against quorum-sensing receptors in Agrobacterium tumefaciens, Pseudomonas aeruginosa, and Vibrio fischeri. Several compounds were identified with significantly heightened activities relative to the lead compounds, and new structure–activity relationships (SARs) were delineated. Notably, 4-substituted N-phenoxyacetyl and 3-substituted N-phenylpropionyl l-homoserine lactones were identified as potent antagonists of TraR and LuxR, respectively.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Grant D. Geske, Margrith E. Mattmann, Helen E. Blackwell,