Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1364604 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
The generation of a series of analogs of erythromycin A (EryA, 2) is described. In this study, we compared two peptide-based catalysts—one originally identified from a catalyst screen (5) and its enantiomer (ent-5)—for the selective functionalization of EryA. The semi-synthetic analogs were subjected to MIC evaluation with two bacterial strains and compared to unfunctionalized EryA.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chad A. Lewis, Janie Merkel, Scott J. Miller,