Article ID Journal Published Year Pages File Type
1364604 Bioorganic & Medicinal Chemistry Letters 2008 5 Pages PDF
Abstract

The generation of a series of analogs of erythromycin A (EryA, 2) is described. In this study, we compared two peptide-based catalysts—one originally identified from a catalyst screen (5) and its enantiomer (ent-5)—for the selective functionalization of EryA. The semi-synthetic analogs were subjected to MIC evaluation with two bacterial strains and compared to unfunctionalized EryA.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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