| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1364747 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
Simplified analogs of YM-26734, a known inhibitor of secreted phospholipase A2 (sPLA2) group IIA, were synthesized and found to also display potent inhibition at low nanomolar concentrations. Analogs were based on the didodecanoylphloroglucinol portion of YM-26734 which contains the predicted active site calcium binding group.
Graphical abstractModeling of YM-26734 in the active site of secreted phospholipase A2 group IIA led to the design and synthesis of simplified analogs retaining nanomolar potency.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Rob C. Oslund, Nathan Cermak, Christophe L.M.J. Verlinde, Michael H. Gelb,