| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1364749 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
A variety of long chain 1,2-diamines and related compounds were synthesized and tested for their activity on fatty acid amide hydrolase (FAAH) and monoacyglycerol lipase (MGL). (2S,9Z)-Octadec-9-ene-1,2-diamine selectively inhibits MGL (Ki 21.8 μμM) without significantly affecting FAAH. This compound exhibited interesting in vivo analgesic and anti-inflammatory properties, suggesting that selective inhibitors of MGL may be valuable novel agents for the treatment of inflammatory pain.
Graphical abstractThe synthesis of a selective MGL inhibitor presenting analgesic and anti-inflammatory activity is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Victoria Magrioti, George Naxakis, Dimitra Hadjipavlou-Litina, Alexandros Makriyannis, George Kokotos,