| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1364763 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
SAR exploration of multiple regions of a tyrosine urea template led to the identification of very potent muscarinic acetylcholine receptor antagonists such as 10b with good subtype selectivity for M3 over M1. The structure–activity relationships (SAR) and optimization of the tyrosine urea series are described.
Graphical abstractSAR exploration of multiple regions of a tyrosine urea template led to the identification of very potent muscarinic acetylcholine receptor antagonists such as 10b with good sub-type selectivity for M3 over M1. The structure–activity relationships (SAR) and optimization of the tyrosine urea series are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Jian Jin, Yonghui Wang, Dongchuan Shi, Feng Wang, Wei Fu, Roderick S. Davis, Qi Jin, James J. Foley, Henry M. Sarau, Dwight M. Morrow, Michael L. Moore, Ralph A. Rivero, Michael Palovich, Michael Salmon, Kristen E. Belmonte, Jakob Busch-Petersen,