| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1364771 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
The stereospecific synthesis of two all-syn-EPA-derived isoprostanes (iPs), 5-epi-8,12-iso-iPF3α-VI 17 and 8,12-iso-iPF3α-VI 18, has been accomplished. These two synthetic probes have been used to discover and identify their presence in human urine. The eventual quantitative measurement of these two iPs may be a valuable index of oxidative stress in people with eicosapentaenoic acid- (EPA) and docosahexaenoic acid- (DHA) enriched phospholipids.
Graphical abstract5-epi-8,12-iso-iPF3α-VI 17 and 8,12-iso-iPF3α-VI 18 were prepared by stereospecific synthesis and used to discover the corresponding novel iPs in human urine.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chih-Tsung Chang, Pranav Patel, Namin Kang, John A. Lawson, Wen-Liang Song, William S. Powell, Garret A. FitzGerald, Joshua Rokach,