Article ID Journal Published Year Pages File Type
1364776 Bioorganic & Medicinal Chemistry Letters 2008 5 Pages PDF
Abstract

A series of novel potent benzimidazole based inhibitors of interleukin-2 T-cell kinase (Itk) were prepared. In this report, we discuss the structure–activity relationship (SAR), selectivity, and cell-based activity for the series. We also discuss the SAR associated with an X-ray structure of one of the small-molecule inhibitors bound to ITK.

Graphical abstractThe SAR study of novel class of Itk inhibitors is discussed.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
, , , , , , , , , , , , , ,