Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1364776 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
A series of novel potent benzimidazole based inhibitors of interleukin-2 T-cell kinase (Itk) were prepared. In this report, we discuss the structure–activity relationship (SAR), selectivity, and cell-based activity for the series. We also discuss the SAR associated with an X-ray structure of one of the small-molecule inhibitors bound to ITK.
Graphical abstractThe SAR study of novel class of Itk inhibitors is discussed.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kevin J. Moriarty, Hidenori Takahashi, Steven S. Pullen, Hnin Hnin Khine, Rosemarie H. Sallati, Ernest L. Raymond, Joseph R. Woska Jr., Deborah D. Jeanfavre, Gregory P. Roth, Michael P. Winters, Lei Qiao, Declan Ryan, Renee DesJarlais, Darius Robinson,