Article ID Journal Published Year Pages File Type
1364789 Bioorganic & Medicinal Chemistry Letters 2008 4 Pages PDF
Abstract

The optimisation of a series of amides for C5a receptor binding and functional activity, and physicochemical properties is described. The initial hit, 1 (IC50 1 μM), was discovered during high throughput screening, from which highly potent C5a receptor antagonists (e.g.14, IC50 5 nM) were developed.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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