Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1364789 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
The optimisation of a series of amides for C5a receptor binding and functional activity, and physicochemical properties is described. The initial hit, 1 (IC50 1 μM), was discovered during high throughput screening, from which highly potent C5a receptor antagonists (e.g.14, IC50 5 nM) were developed.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Julian Blagg, Charles Mowbray, David C. Pryde, Gary Salmon, Esther Schmid, David Fairman, Kevin Beaumont,