| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1364790 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Starting from 2, several highly potent C5a receptor antagonists were synthesised through α-amide substitution. Attempts to increase the polarity of these compounds through the introduction of basic centres or incorporation into weakly basic heterocycles is described.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Julian Blagg, Charles Mowbray, David Pryde, Gary Salmon, David Fairman, Esther Schmid, Kevin Beaumont,