| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1364799 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
The synthesis and structure–activity relationship of a series of carbamate potentiators of α4β2 nAChR is reported herein. These compounds were highly selective for α4β2 over other nAChR subtypes. In addition, compounds increased the response of α4β2 nAChRs to acetylcholine, as measured with patch–clamp electrophysiology.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Stephanie K. Springer, Katrina S. Woodin, Virginia Berry, Alessandro A. Boezio, Lei Cao, Kristie Clarkin, Jean-Christophe Harmange, Markus Hierl, Johannes Knop, Annika B. Malmberg, Jeff S. McDermott, Hung Q. Nguyen, Daniel Waldon, Brian K. Albrecht,