| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1364801 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Investigation of a series 6-[2-(4-aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones has led to the discovery of potent 5-HT1A/1B/1D receptor antagonists with and without additional SerT affinity. Modulation of the different target activities gave compounds with a range of profiles suitable for further in vivo characterization.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![6-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: Dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors](/preview/png/1364801.png "First Page Preview: 6-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: Dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors")
Authors
Steven M. Bromidge, Barbara Bertani, Manuela Borriello, Stefania Faedo, Laurie J. Gordon, Enrica Granci, Matthew Hill, Howard R. Marshall, Luigi P. Stasi, Valeria Zucchelli, Giancarlo Merlo, Alessia Vesentini, Jeannette M. Watson, Laura Zonzini,