Article ID Journal Published Year Pages File Type
1364803 Bioorganic & Medicinal Chemistry Letters 2008 4 Pages PDF
Abstract

We have developed a new methodology for producing new molecules that bind to dsDNA using DNA-templated click chemistry. The click reactions between the minor groove binding peptide and acridine intercalators were accelerated by the addition of dsDNA. Furthermore, the resulting peptide–acridine conjugate showed a slightly stronger binding to dsDNA. These results indicate that the DNA-templated click chemistry is applicable for screening new binding molecules.

Graphical abstractWe have developed a new methodology for producing new molecules that bind to dsDNA using the DNA-templated click chemistry.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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