Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1364803 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
We have developed a new methodology for producing new molecules that bind to dsDNA using DNA-templated click chemistry. The click reactions between the minor groove binding peptide and acridine intercalators were accelerated by the addition of dsDNA. Furthermore, the resulting peptide–acridine conjugate showed a slightly stronger binding to dsDNA. These results indicate that the DNA-templated click chemistry is applicable for screening new binding molecules.
Graphical abstractWe have developed a new methodology for producing new molecules that bind to dsDNA using the DNA-templated click chemistry.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shuhei Imoto, Tomoya Hirohama, Fumi Nagatsugi,