Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1364967 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
The synthesis and biological evaluation of a series of N-alkyl glycine amide analogs as LTA4-h inhibitors and the importance of the introduction of a benzoic acid group to the potency and pharmacokinetic parameters of our analogs are described. The lead compound in the series, 4q, has excellent potency and oral bioavailability.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Bin Ye, John Bauman, Ming Chen, David Davey, Seock-Kyu Khim, Beverly King, Thomas Kirkland, Monica Kochanny, Amy Liang, Dao Lentz, Karen May, Lisa Mendoza, Gary Phillips, Victor Selchau, Sabine Schlyer, Jih-Lie Tseng, Robert G. Wei, Hong Ye,