Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1364968 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
The synthesis and biological evaluation of a series of aryl diamines as inhibitors of LTA4-h inhibitors are described. The optimization which led to the identification of the optimal para-substitution on the diphenyl ether moiety and diamine spacer is discussed. The resulting compounds such as 3l have excellent enzyme and cellular potency as well as desirable pharmacokinetic properties.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Seock-Kyu Khim, John Bauman, Jarred Evans, Beverly Freeman, Beverly King, Thomas Kirkland, Monica Kochanny, Dao Lentz, Amy Liang, Lisa Mendoza, Gary Phillips, Jih-Lie Tseng, Robert G. Wei, Hong Ye, Limei Yu, John Parkinson, William J. Guilford,