| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1364974 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Design and synthesis of a novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives are reported and their in vitro thyroid hormone receptor selectivity has been evaluated in the thyroid luciferase receptor assay. The 3-[3,5-dichloro-4-(4-hydroxy-3-isopropylphenoxy)-phenylamino]-4-hydroxy-cyclobut-3-ene-1,2-dione 21 has shown selectivity towards thyroid hormone receptor β.
Graphical abstractDesign and synthesis of a novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives are reported and their thyroid hormone receptor selectivity has been evaluated. 3-[3,5-Dichloro-4-(4-hydroxy-3-isopropylphenoxy)-phenylamino]-4-hydroxy-cyclobut-3-ene-1,2-dione 21 has shown selectivity towards thyroid hormone receptor β.Figure optionsDownload full-size imageDownload as PowerPoint slide
