| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1364984 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
Bioactivity guided fractions of cell-free hemolymph of bacterially challenged marine mussel, Perna viridis led to the isolation of a novel quaternary alkaloid 1, which was identified by its spectral data. The isolated molecule 1 has been found to be a potent serine protease inhibitor (SPI) showing IC50 and Ki values of 102.5 and 97.1–104.68 μM, respectively. The Et/Ki value of SPI is 6.3, whereas Et/Km value is 1.04. The Van’t Hoff analysis showed that the value of Ki decreases with increase in temperature, and the binding of the inhibitor is entropically driven.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
M.S. Khan, U. Goswami, S.R. Rojatkar, M.I. Khan,