Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1365012 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
Structural analysis of oxazolomycin and simpler fragments containing a common 3-hydroxy-2,2-dimethylpropanamide moiety has indicated that a U-shaped conformation is preferred, in some cases stabilised by hydrogen bonding between the N–H and O–H residues, as shown by a combination of molecular modelling, NMR spectroscopic and single crystal X-ray analysis. A direct synthesis of this unit has been established via the opening of β-lactones by a range of amines, and their antibacterial activity been shown to vary with the hydrophobic character of the substituents.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Claire L. Bagwell, Mark G. Moloney, Amber L. Thompson,