| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365024 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
A new series of H3 antagonists derived from the natural product Conessine are presented. Several compounds from these new series retain the potency and selectivity of earlier diamine based analogs while exhibiting improved PK characteristics. One compound (3u) demonstrated functional antagonism of the H3 receptor in an in vivo pharmacological model.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Vincent J. Santora, Jonathan A. Covel, Rena Hayashi, Brian J. Hofilena, Jason B. Ibarra, Michelle D. Pulley, Michael I. Weinhouse, Graeme Semple, Albert Ren, Guilherme Pereira, Jeffrey E. Edwards, Marissa Suarez, John Frazer, William Thomsen,