| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1365036 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
This paper describes the improvement of cell potency in a class of allosteric Akt 1 and 2 inhibitors. Key discoveries include identifying the solvent exposed region of the molecule and appending basic amines to enhance the physiochemical properties of the molecules. Findings from the structure–activity relationships are discussed.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tony Siu, Jun Liang, Jeannie Arruda, Yiwei Li, Raymond E. Jones, Deborah Defeo-Jones, Stanley F. Barnett, Ronald G. Robinson,