Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1365042 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
The synthesis and development of a novel class of molecules that inhibit anthrax edema factor, an adenylyl cyclase, is reported. These molecules are derived from the initial discovery that histidine and imidazole adducts of the prostaglandin PGE2 reduce the net secretory response of cholera toxin-challenged mice and act directly on the action of anthrax edema factor, a calmodulin-dependent adenylyl cyclase. The simple enones examined in this letter were prepared by palladium-catalyzed Suzuki reaction.
Graphical abstractThe development of series of small molecule inhibitors of anthrax edema factor is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Maria Estrella Jimenez, Kathryn Bush, Jennifer Pawlik, Laurie Sower, Johnny W. Peterson, Scott R. Gilbertson,