Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1365044 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
The design, synthesis, and SAR of a series of ring-constrained norepinephrine reuptake inhibitors are described. A substantially rigid inhibitor with potent functional activity at the transporter (IC50 = 8 nM) was used to develop a model for the distance and orientation of key features necessary for interaction with the norepinephrine transporter (NET).
Graphical abstractA rigid ring-constrained norepinephrine reuptake inhibitor with potent functional activity at the transporter (IC50 = 8 nM) was used to develop a model for the distance and orientation of key features necessary for interaction with NET.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dongpei Wu, Joseph Pontillo, Brett Ching, Sarah Hudson, Yinghong Gao, Beth A. Fleck, Kathleen Gogas, Warren S. Wade,